Austin Crinklaw

Bioinformatics Scientist & Software Engineer

Biography

Hi! I'm Austin, I'm a San Diego based software developer with a focus on bioinformatics specific applications. I started my career at the bench at UCSD working on E. Coli genetics but quickly found my passion for the computational side of biology. I'm a big fan of working in the startup space and have a passion for applying my problem solving skills to the many challenges scientists face trying to improve public health and advance science. In my free time, I enjoy playing competitive video games, brewing beer, producing music, and spending time with my wife and dog.

Education

Bachelor of Science, Bioinformatics

UCSD

September 2015 - June 2018

Skills

Programming Languages

Python
Rust
JavaScript
TypeScript
React
C++

Bioinformatics

NGS
RNA-Seq
PacBio Long Read
Single-Cell
Computational Immunology
CRISPR/Cas9 gRNA design
siRNA design

Other Tech

AWS
Docker
CI/CD
NextJS
GNU/Linux
PostgreSQL

Software Projects

siRCH™ Platform

Comprehensive web application for designing and tracking the development of siRNA therapeutics.

React
Python
AWS
View Project

TCRMatch

Command line tool for predicting T-Cell Receptor specificity.

C++
View Project

RustMelt5

Rust library for computing the melting temperature of oligonucleotides.

Rust
View Project

ARC

Python package for identifying immune system related proteins from unknown sequences.

Python
View Project

Experience

Empirico Inc

Senior Bioinformatics Scientist

March 2023 - Present

  • Technical and small team lead for development of internal web application facilitating the development of siRNA therapeutics.
  • Designed and implemented software architecture from the ground up with a focus on best practices and domain driven design.
  • Implemented automated CI/CD and defined team strategies for software development lifecycle.
  • Demonstrated full-stack software engineering expertise.

Jumpcode Genomics

Research Associate III

March 2022 - March 2023

  • Designed and implemented Python / NextFlow pipelines for CRISPR/Cas9 gRNA sequence design.
  • Overhauled AWS infrastructure, reducing compute costs by 50%.
  • Analyzed long-read RNA-Seq, specifically PacBio IsoSeq / MAS-Seq.

1859 inc.

Senior Associate Scientist

September 2021 - March 2022

  • Maintained and improved Python application for analysis of custom, artificial short read DNA sequences (DNA-encoded libraries).
  • Created web applications for data visualization and pipeline orchestration.

LJI, Peters Lab

Research Tech

February 2018 - September 2021

  • Implemented new method for T-Cell Receptor specificity prediction
  • Created Python package for identifying immune system related proteins from unknown sequences.
  • Developed RNA-Seq pipeline for allele-specific HLA expression.